Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
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New insights into HIV-1-primary skin disordersLower levels of gamma interferon expressed by a pseudotyped single-cycle simian immunodeficiency virus enhance immunogenicity in rats.Animal models for HIV/AIDS researchHigh natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.Susceptibility of mink (Mustera vision)-derived cells to replication by human immunodeficiency virus type 1Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicityHIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcriptionRodent models for HIV-associated neurocognitive disorders.Multiple restrictions of human immunodeficiency virus type 1 in feline cells.Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop.In vivo platforms for analysis of HIV persistence and eradication.Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.Capsid-dependent and -independent postentry restriction of primate lentivirus tropism in rodent cellsGenetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injuryAntibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model.Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection.Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivoRole of macrophages in HIV infection and persistence.Retroviral restriction and dependency factors in primates and carnivores.Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.Animal models in virus research: their utility and limitations.Adding new dimensions: towards an integrative understanding of HIV-1 spread.Latest animal models for anti-HIV drug discovery.HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes.Humanized mice for HIV and AIDS research.Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages.Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.The antiretroviral potency of APOBEC1 deaminase from small animal species.Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor NefThe Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research.
P2860
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P2860
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@ast
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@en
type
label
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@ast
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@en
prefLabel
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@ast
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@en
P2093
P2860
P50
P356
P1476
Progress toward a human CD4/CC ...... immunodeficiency virus type 1.
@en
P2093
Brian G Herndier
Chia-Lin Tsou
Dan R Littman
Frank J Welte
Israel F Charo
John D Scarborough
Kathryn S Patton
Mario Stevenson
Mark A Goldsmith
Mark E Sharkey
P2860
P304
P356
10.1084/JEM.20011549
P407
P577
2002-03-01T00:00:00Z