Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice
about
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteinsRemoval of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cellsAdoptive immunotherapy for cancer: building on successThe role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic useRegulating the immune system via IL-15 transpresentationNatural killer cell biology: an update and future directionsNK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.Survival adjustment of mature dendritic cells by IL-15.Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activityIntramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cellsGeneration of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha.Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.Immunobiology of the TAM receptors.Memory-like responses of natural killer cells.IL-15 participates in the respiratory innate immune response to influenza virus infectionHuman NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence.Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy.Activation-specific metabolic requirements for NK Cell IFN-γ production.NK cells and immune "memory"The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cellsHematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cellsTissue-resident natural killer cells and their potential diversityAugmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha.Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo.NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanismIn vivo survival and homeostatic proliferation of natural killer cells.Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasisHuman Renal Normal, Tumoral, and Cancer Stem Cells Express Membrane-Bound Interleukin-15 Isoforms Displaying Different Functions.Development, trafficking, and function of memory T-cell subsets.Reciprocal regulation between natural killer cells and autoreactive T cells.IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.Modeling the pharmacokinetic-pharmacodynamic relationship of the monoclonal anti-macaque-IL-15 antibody Hu714MuXHu in cynomolgus monkeys.Human natural killer cell development.Human natural killer cells.
P2860
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P2860
Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@ast
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@en
type
label
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@ast
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@en
prefLabel
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@ast
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@en
P2093
P2860
P356
P1476
Interleukin (IL)-15R[alpha]-de ...... t IL-15R[alpha]-deficient mice
@en
P2093
David L Boone
James P Lodolce
Marcia Chien
Patrick R Burkett
Sophia Chai
P2860
P304
P356
10.1084/JEM.20021836
P407
P577
2003-04-14T00:00:00Z