Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
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Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence programInnate immune responses in the ageing lung.Latest progress in tyrosine kinase inhibitorsMethionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cellsRapamycin extends life and health in C57BL/6 miceFrom rapalogs to anti-aging formula.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.Gerosuppression in confluent cells.Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.ATF4 activity: a common feature shared by many kinds of slow-aging miceDAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout LifeFasting levels of hepatic p-S6 are increased in old miceGeroconversion: irreversible step to cellular senescenceComparison of rapamycin schedules in mice on high-fat diet.Rejuvenating immunity: "anti-aging drug today" eight years later.Koschei the immortal and anti-aging drugsDual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.Rapamycin, anti-aging, and avoiding the fate of TithonusEvaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress.Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium.M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts.Immunosuppressants in cancer prevention and therapyWhile reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts.
P2860
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P2860
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@ast
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@en
type
label
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@ast
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@en
prefLabel
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@ast
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@en
P2093
P2860
P1476
Enteric-delivered rapamycin en ...... gh reduced cellular senescence
@en
P2093
Carlos J Orihuela
Cecilia A Hinojosa
Richard A Miller
Sabrina Van Roekel
Santanu Bose
Steven N Austad
Victoria Mgbemena
P2860
P304
P356
10.1016/J.EXGER.2012.08.013
P577
2012-09-07T00:00:00Z