Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.
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The analysis of clonal expansions in normal and autoimmune B cell repertoiresSomatic mutagenesis in autoimmunitySecondary receptor editing in the generation of autoimmunityB cell receptor editing in tolerance and autoimmunitySpontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytesPatterns of receptor revision in the immunoglobulin heavy chains of a teleost fishThe evolution of human anti-double-stranded DNA autoantibodiesReceptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.Revising B cell receptorsStructural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cellsThe role of rearrangement at the second Ig heavy chain locus in maintaining B cell tolerance to DNA.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Receptor revision and systemic lupus.Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus.Autoantibodies: Focus on anti-DNA antibodies.Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production.Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells.Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in FaslThe broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.Editing and escape from editing in anti-DNA B cells.Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivityCompetence and competition: the challenge of becoming a long-lived plasma cell.Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Contributions of B cells to lupus pathogenesisTrials and Tribulations with VH Replacement.C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes.Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus.
P2860
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P2860
Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@ast
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@en
type
label
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@ast
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@en
prefLabel
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@ast
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@en
P2093
P2860
P356
P1476
Somatic mutation and light cha ...... d DNA transgenic MRL/lpr mice.
@en
P2093
P2860
P304
P356
10.1084/JEM.190.5.691
P407
P577
1999-09-01T00:00:00Z