The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.
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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationFunctional roles of Syk in macrophage-mediated inflammatory responsesHyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growthShb links SLP-76 and Vav with the CD3 complex in Jurkat T cellsA novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fc epsilon receptorTyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcriptionMembrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.Vav1 is a component of transcriptionally active complexes.Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation.Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membraneVav1 regulates phospholipase cgamma activation and calcium responses in mast cells.Vav proteins, adaptors and cell signaling.Adapters in the organization of mast cell signaling.A mechanistic model of early FcεRI signaling: lipid rafts and the question of protection from dephosphorylation.Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK.Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.The role of Syk kinase in ultraviolet-mediated skin damageLipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.The mast cell: an antenna of the microenvironment that directs the immune response.Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activationFunction of the nucleotide exchange activity of vav1 in T cell development and activation.Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness.Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.Compartmentalization of ITAM and integrin signaling by adapter molecules.Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinaseVav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis.Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor.Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NFMunc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes
P2860
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P2860
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@ast
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@en
type
label
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@ast
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@en
prefLabel
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@ast
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@en
P2093
P2860
P356
P1476
The Src homology 2 domain of V ...... c-Jun NH(2)-terminal kinase 1.
@en
P2093
M J Peirce
R Arudchandran
R P Siraganian
P2860
P356
10.1084/JEM.191.1.47
P407
P577
2000-01-01T00:00:00Z