Receptor editing occurs frequently during normal B cell development.
about
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingA novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins.Primary immunoglobulin repertoire development: time and space matterB cell receptor editing in tolerance and autoimmunityReceptor editing is the main mechanism of B cell tolerance toward membrane antigensSecondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosusReceptor selection in B and T lymphocytes.Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.The immune tolerance network and rheumatic disease: immune tolerance comes to the clinic.Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoireReceptor editing in lymphocyte development and central tolerance.Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia.Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus.Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The Igκ gene enhancers, E3' and Ed, are essential for triggering transcriptionA multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanismDiverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificitiesB cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis opticaNegative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escapeAlternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells.Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Efficient generation of B lymphocytes by recognition of self-antigens.Regulation of activation and recombination of the murine Igkappa locus.VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation.Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cellsIFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.Persistent expression of autoantibodies in SLE patients in remission.Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.Igkappa allelic inclusion is a consequence of receptor editing.Reduced receptor editing in lupus-prone MRL/lpr miceReplication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansionBruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouseAutoreactive B cells in the marginal zone that express dual receptors
P2860
Q24569801-B18A07D5-7AB8-46DE-A607-FC554BEF4087Q24794416-5A1197AD-58FF-42A0-AC16-BBB9B74CA9EEQ27022157-C9021303-5019-4CF5-A686-51D376CC3CE9Q27692084-EA60FBFA-7AC9-44D9-A7E5-19B960A85AE5Q28262805-972537F2-8671-4458-8685-0A9F9CD4D374Q30708822-55507B71-2021-4921-869E-A03E77820BACQ33222423-3093BC0A-A2D3-4942-8271-2CCE2851503DQ33932667-6149BE62-D6D0-414F-8C5F-E4FA9E0AE225Q33979850-8C12F7A7-0D1E-4905-9F63-B3C2A9137389Q34338802-162230D8-1C6A-41ED-AECB-E32835E739C2Q34436439-3060FF1B-ECCA-4CE8-84B1-D5DBD782FAD8Q34568574-75621854-73E9-4564-A1E0-7F29188FF0CBQ34572326-668CD303-2B35-47AF-AB47-2E45F5FADB90Q34578320-D5BF08EE-28BE-449A-A270-B0458072B398Q34650823-756B333B-437E-4B32-B3DD-01F06BAF6D7DQ34681437-4CA9E66C-0B67-4132-9DF5-E5828C5F8351Q34686905-4B8F3BF5-E47F-44AC-89C2-39B87395054EQ34827298-250FBB9E-07E3-4824-B612-FD9AEB48B922Q34983943-F85803AF-C9B7-46B8-B8D4-C357D34631FDQ35032627-C025979C-94F5-448E-B774-9B0FE75201E5Q35086472-2A435CF6-3BA6-4915-847B-674D62E9C9B1Q35160339-C6BF58DD-BF14-4352-9AEB-47F076454C9AQ35234452-216D49EA-8148-4FD9-AFF9-EC5DF51E30AAQ35582239-857E9D74-C60B-42D8-833F-B441DF7B8D8FQ35666699-A376B151-D36D-469C-AADF-1F326ABA0C42Q35666716-E7F26831-6AE2-48EF-AFFD-E89A215DA2AFQ35784452-9F57705A-ADC7-466C-AD67-2619F36D4A68Q35825782-F71E6201-F685-4485-AE27-A628A3E29A36Q35830435-FA2D03B0-AC1C-4971-A800-7A24360D8BF7Q35931436-3B141A1E-4EF2-4E16-A96E-3846C9A6AD20Q35951839-056675DA-FE35-4720-8FAF-E65A6935673AQ35974118-3C577339-04A8-4B86-87B7-3252BC15E4B5Q36121801-862C357B-2525-406F-B92F-2651FF4DE2D6Q36227941-B63A5870-ADBD-4E50-A5EE-38A70510EC82Q36228744-DF8426B5-322E-4A67-B751-02373776A9F4Q36228958-1D9C5DCB-15A2-42B9-960E-0D8900EA2801Q36229153-CCAA98AA-D1D7-480D-B50B-F4156DF62938Q36267196-99E654B1-C1AE-426F-A1E4-A519A0F7A8C3Q36369010-24A40134-F7C4-42F5-B710-191559BA357EQ36369869-734C9BC2-0747-4EE5-A246-A0A46E34AA89
P2860
Receptor editing occurs frequently during normal B cell development.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Receptor editing occurs frequently during normal B cell development.
@ast
Receptor editing occurs frequently during normal B cell development.
@en
type
label
Receptor editing occurs frequently during normal B cell development.
@ast
Receptor editing occurs frequently during normal B cell development.
@en
prefLabel
Receptor editing occurs frequently during normal B cell development.
@ast
Receptor editing occurs frequently during normal B cell development.
@en
P2860
P356
P1476
Receptor editing occurs frequently during normal B cell development
@en
P2093
M W Retter
P2860
P304
P356
10.1084/JEM.188.7.1231
P407
P50
P577
1998-10-01T00:00:00Z