B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
about
Human antibody production in transgenic animalsB cell receptor editing in tolerance and autoimmunityDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsCD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappaDeletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in transSomatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Alternative mechanisms of receptor editing in autoreactive B cells.Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilitiesThe catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombinationSkewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Immune function in mice lacking the perforin geneHistone reader BRWD1 targets and restricts recombination to the Igk locus.RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance.Light chain replacement: a new model for antibody gene rearrangementInsertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangementExpression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements.Selection at multiple checkpoints focuses V(H)12 B cell differentiation toward a single B-1 cell specificityEditing anti-DNA B cells by VlambdaxReceptor editing occurs frequently during normal B cell development.An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune systemUnexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice.Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact.Adoptive Transfer of Memory B Cells.Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiationThe degree of CD4+ T cell autoreactivity determines cellular pathways underlying inflammatory arthritisFunctionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM.Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signalingA surrogate 15 kDa JC kappa protein is expressed in combination with mu heavy chain by human B cell precursors.Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.
P2860
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P2860
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@ast
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@en
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@nl
type
label
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@ast
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@en
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@nl
prefLabel
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@ast
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@en
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
@nl
P2093
P2860
P1433
P1476
B cell development in mice that lack one or both immunoglobulin kappa light chain genes
@en
P2093
C Kurahara
J F Loring
M Trounstine
P2860
P304
P356
10.1002/J.1460-2075.1993.TB05722.X
P407
P577
1993-03-01T00:00:00Z