An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system
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B cell receptor editing in tolerance and autoimmunityToll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.Central B-cell tolerance: where selection begins.The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Receptor editing in lymphocyte development and central tolerance.Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.Alternative mechanisms of receptor editing in autoreactive B cells.Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.VH replacement in primary immunoglobulin repertoire diversification.Heavy-chain receptor editing unbound.Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escapeSkewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.Reduced receptor editing in lupus-prone MRL/lpr miceDual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.Receptor editing and genetic variability in human autoreactive B cells.Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivityPrimer: mechanisms of immunologic tolerance.Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiationNF-kappaB activity marks cells engaged in receptor editing.Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.Tolerance checkpoints in B-cell development: Johnny B good.Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM.Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.The regulation of autoreactive B cells during innate immune responses.
P2860
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P2860
An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@ast
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@en
type
label
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@ast
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@en
prefLabel
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@ast
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@en
P2093
P2860
P356
P1476
An immunoglobulin C kappa-reac ...... ormal polyclonal immune system
@en
P2093
Amanda Gavin
Djemel Ait-Azzouzene
Jorieke Peters
José Luis Vela
Laurent Verkoczy
Patrick Skog
P2860
P304
P356
10.1084/JEM.20041854
P407
P50
P577
2005-02-28T00:00:00Z