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A DNA polymerase beta mutant from colon cancer cells induces mutations.

A DNA polymerase beta mutant from colon cancer cells induces mutations.

http://www.wikidata.org/entity/Q37646895

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DNA polymerase family X: function, structure, and cellular roles Base excision repair and cancer Human DNA Polymerase Mutations Allowing Efficient Abasic Site Bypass DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation Hypothesis driven single nucleotide polymorphism search (HyDn-SNP-S).A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.Colorectal carcinogenesis--update and perspectives.Variation in base excision repair capacity.Substrate-dependent millisecond domain motions in DNA polymerase β.Human POLB gene is mutated in high percentage of colorectal tumors.Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.Sequence context-specific mutagenesis and base excision repair.Population-specific variation in haplotype composition and heterozygosity at the POLB locus.Targeting DNA polymerase ß for therapeutic intervention.Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.Base excision repair targets for cancer therapy Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Why nature really chose phosphate.Cellular roles of DNA polymerase beta.DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.Base excision repair of oxidative DNA damage: from mechanism to disease.DNA polymerase β promoter mutations and transcriptional activity in esophageal squamous cell carcinoma.Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.Genome instability caused by a germline mutation in the human DNA repair gene POLB.Polμ tumor variants decrease the efficiency and accuracy of NHEJ.The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

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A DNA polymerase beta mutant from colon cancer cells induces mutations.

http://www.wikidata.org/entity/Q37646895

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 April 2004

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@en

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@nl

type

label

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@en

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@nl

prefLabel

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@en

A DNA polymerase beta mutant from colon cancer cells induces mutations.

@nl

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PNAS.0308571101

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Proceedings of the National Academy of Sciences of the United States of America

P1476

A DNA polymerase beta mutant from colon cancer cells induces mutations.

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Daniela Starcevic

http://www.w3.org/2001/XMLSchema#string

Joann B Sweasy

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Mausumi Maitra

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Shu-Xia Li

http://www.w3.org/2001/XMLSchema#string

Tieming Lang

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P2860

Instability and decay of the primary structure of DNA

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

A variant of DNA polymerase beta acts as a dominant negative mutant

A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability

A novel role of XRCC1 in the functions of a DNA polymerase beta variant

DNA polymerase beta mutations in human colorectal cancer

Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection.

Keynote: past, present, and future aspects of base excision repair.

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6074-6079

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scholarly article

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10.1073/PNAS.0308571101

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