Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.
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Developmental potential for endomorphin opioidmimetic drugsFurther studies on lead compounds containing the opioid pharmacophore Dmt-Tic.Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreDelta-Opioid Receptor (δOR) Targeted Near-Infrared Fluorescent Agent for Imaging of Lung Cancer: Synthesis and Evaluation In Vitro and In Vivo.Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compoundsNew 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligandsEngineering endomorphin drugs: state of the art.A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-TicUnderstanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502)New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).Molecular Pharmacology of δ-Opioid Receptors.Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5.Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles.Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging.
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P2860
Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@ast
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@en
type
label
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@ast
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@en
prefLabel
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@ast
Delta opioidmimetic antagonist ...... ltraselective opioid peptides.
@en
P2093
P2860
P356
P1433
P1476
Delta opioidmimetic antagonist ...... ultraselective opioid peptides
@en
P2093
O Crescenzi
P A Temussi
R Guerrini
S D Bryant
S Salvadori
T Tancredi
P2860
P2888
P304
P356
10.1007/BF03401608
P407
P577
1995-09-01T00:00:00Z