Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.
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Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cellsPharmacology of nociceptin and its receptor: a novel therapeutic targetStructural basis for bifunctional peptide recognition at human δ-opioid receptorConformational analysis of the endogenous mu-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modeling.Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptorsEvolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreBi- or multifunctional opioid peptide drugs.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.One-pot isomerization-cross metathesis-reduction (ICMR) synthesis of lipophilic tetrapeptidesStereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1.New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligandsOrganic chemistry and biology: chemical biology through the eyes of collaboration.Frog skin opioid peptides: a case for environmental mimicry.Dmt and opioid peptides: a potent alliance.The conformation of enkephalin bound to its receptor: an "elusive goal" becoming reality.Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists.Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism.Opioid peptide-derived analgesicsDelta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.Modeling and simulation of the human delta opioid receptor.Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).Molecular Pharmacology of δ-Opioid Receptors.N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.Mu opioids and their receptors: evolution of a concept.Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions.The role of crystallography in drug designDesign of peptide and peptidomimetic ligands with novel pharmacological activity profiles.Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors.Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.Opioid receptor targeting ligands for pain management: a review and update.Glycosylation improves the central effects of DAMGO.The delta opioid receptor tool box.Cyclic Opioid Peptides.Characterization of opioid receptor types and subtypes with new ligands.Molecular organization of receptors. Efficacy, agonists, and antagonists.Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts.
P2860
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P2860
Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Differential stereochemical re ...... selective peptide antagonists.
@en
Differential stereochemical re ...... selective peptide antagonists.
@nl
type
label
Differential stereochemical re ...... selective peptide antagonists.
@en
Differential stereochemical re ...... selective peptide antagonists.
@nl
prefLabel
Differential stereochemical re ...... selective peptide antagonists.
@en
Differential stereochemical re ...... selective peptide antagonists.
@nl
P2093
P2860
P356
P1476
Differential stereochemical re ...... selective peptide antagonists.
@en
P2093
B C Wilkes
B J Marsden
G Weltrowska
P W Schiller
T M Nguyen
P2860
P304
11871-11875
P356
10.1073/PNAS.89.24.11871
P407
P577
1992-12-01T00:00:00Z