New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. - Wikidata - wikimedia - TriplyDB

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

http://www.wikidata.org/entity/Q36731648

about

Endogenous opiates and behavior: 2006 Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine, Naltrexone, and Naloxone at μ, δ, and κ Opioid Receptors Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.Bi- or multifunctional opioid peptide drugs.Opioid-receptor-heteromer-specific trafficking and pharmacology.Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.Opioid receptor targeting ligands for pain management: a review and update.Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors.

P2860

Q28752585-BD81C53E-7B53-4391-8A7E-10325AD7CD73 Q29542291-6C4AF438-0198-448A-9ABF-703D06C23F2D Q33693780-7A3A5E98-5794-4B20-A189-480929C3AC15 Q33735205-FFF0E019-1745-4A1E-A471-37148198DAD2 Q33767037-C8E8D18B-CC1A-46FA-B9AB-E906518D8B16 Q33978499-CF16CF7D-C35D-4899-A966-0DD2EB3DB239 Q34559481-2A9B500E-FC30-4652-A35D-93C89C0ED136 Q36156405-31B53237-980D-461D-A9AF-6B3494A4BF73 Q36648622-DFD7473D-04D8-44D1-8873-7BC4625D3E3B Q38028661-4F5287D5-E5C6-4428-A35E-5B39A946A6D3 Q39409844-EF1C6A23-CD52-43A9-99D6-A7A068310C4F Q42734840-585B68CB-5991-4A1D-876D-97C871BB1F69

P2860

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

http://www.wikidata.org/entity/Q36731648

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@ast

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@en

type

label

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@ast

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@en

prefLabel

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@ast

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@en

P1433

Q36731648-BA5AA22F-66D0-4384-AAB9-10844625FC8F

P1476

Q36731648-1AE3E5DD-3961-4D3D-AB92-E62995F59E48

P2093

Q36731648-218F967B-745E-44C4-9D99-492F9EB8E490

Q36731648-61D5D3BE-AC86-4C57-A582-9E6BC4CCB849

Q36731648-72480C95-371D-4955-BAC5-0E46D8DF62DE

Q36731648-968BAF45-B8CE-4A37-9643-3352D3ABD65E

Q36731648-BFE37941-C0CB-4A9F-BC48-850B07364620

Q36731648-E47BAD97-C266-4B7F-A7E6-AA520B20378F

P2860

Q36731648-06513CCE-BB5E-4323-A29E-6AE110FB51F6

Q36731648-0822F4C2-6696-4150-A975-A6A192D9C8EE

Q36731648-1770CE5E-438A-451B-9A9D-82F56CF90BFE

Q36731648-1A8EA4DD-8542-4BBD-A1AE-17E0B8BC938F

Q36731648-1B461DD3-DC9B-4B54-BB32-F29B8C457F69

Q36731648-3F447B29-E876-4B98-BDF0-634B740341A1

Q36731648-4C1A7D93-F2A6-4C91-AA1B-31B859BB9C2B

Q36731648-4DD22011-7823-4EF7-B33A-476A49D083FB

Q36731648-6372C415-893D-4EE5-8D8B-86F18C347DC6

Q36731648-6B909B3D-9B11-4A30-8DCC-10D3B90F0ECD

P304

Q36731648-AA37545F-0AD9-4EA1-80B5-4DD0212D7EC7

P31

Q36731648-3CF746C3-2E2F-4F73-8CFB-CD43E101ADAE

P356

Q36731648-5AF71567-3676-4CD1-B589-028EE019D989

P407

Q36731648-4E9FDB21-4EFB-4D43-97D7-F03E9F4940BD

P433

Q36731648-E671AF3D-B3D3-4FE0-9512-CCCA41AEC6F9

P478

Q36731648-EFE6D9D0-799E-4610-B7D8-3ECF5ADC131A

P50

Q36731648-3DA4D46B-E874-4097-AF26-BDB949501AB8

Q36731648-509E7E46-E223-4AA8-9AAE-5B7EDFB7A0A0

P577

Q36731648-4BDBFCA7-B5DA-4CBF-9475-9C72ED5979CB

P5875

Q36731648-7AA510A4-B40A-424A-8CBB-55708EE4E968

P698

Q36731648-928DC804-EE77-415F-AD10-41AA4C53D866

P932

Q36731648-F5418B18-17E8-4C90-B32B-247930BB59DF

P356

P1433

Journal of Medicinal Chemistry

P1476

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

@en

P2093

Brian I Knapp

http://www.w3.org/2001/XMLSchema#string

Gianfranco Balboni

http://www.w3.org/2001/XMLSchema#string

Jean M Bidlack

http://www.w3.org/2001/XMLSchema#string

John L Neumeyer

http://www.w3.org/2001/XMLSchema#string

Lawrence H Lazarus

http://www.w3.org/2001/XMLSchema#string

Xuemei Peng

http://www.w3.org/2001/XMLSchema#string

P2860

Can we rationally design promiscuous drugs?

6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

Opioids and their complicated receptor complexes.

From magic bullets to designed multiple ligands.

Designed multiple ligands. An emerging drug discovery paradigm.

Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.

Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.

Synthesis and antinociceptive activity of orally active opioid peptides: improvement of oral bioavailability by esterification.

P304

5640-5643

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM0605785

http://www.w3.org/2001/XMLSchema#string

P407

P433

18

http://www.w3.org/2001/XMLSchema#string

P478

49

http://www.w3.org/2001/XMLSchema#string

P50

Claudio Trapella

Severo Salvadori

P577

2006-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6846823

http://www.w3.org/2001/XMLSchema#string

P698

16942040

http://www.w3.org/2001/XMLSchema#string

P932

2435260

http://www.w3.org/2001/XMLSchema#string