Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop
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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateA functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationNovel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat.Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy.Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.Intraneuronal Abeta42 accumulation in human brain.Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formationRetinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasomePost-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP.Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sitesClinical-pathologic correlations in vascular cognitive impairment and dementiaIntraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer's Disease.Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse modelThe discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.Alzheimer's Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition.Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy
P2860
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P2860
Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Characterization of new polycl ...... se and cerebral amyloid angiop
@ast
Characterization of new polycl ...... se and cerebral amyloid angiop
@en
type
label
Characterization of new polycl ...... se and cerebral amyloid angiop
@ast
Characterization of new polycl ...... se and cerebral amyloid angiop
@en
prefLabel
Characterization of new polycl ...... se and cerebral amyloid angiop
@ast
Characterization of new polycl ...... se and cerebral amyloid angiop
@en
P2093
P2860
P921
P356
P1433
P1476
Characterization of new polycl ...... ebral amyloid angiopathy cases
@en
P2093
J M Warter
J Martinez
J Vizzavona
P2860
P2888
P304
P356
10.1007/BF03401708
P407
P577
1997-10-01T00:00:00Z