Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating
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The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1aThe tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinityAcid-sensing ion channels in pain and disease.Structure and activity of the acid-sensing ion channelsPore architecture and ion sites in acid-sensing ion channels and P2X receptorsIon transporters in brain tumorsA combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cellsIon conduction and selectivity in acid-sensing ion channel 1.PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner.Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.Expression and activity of acid-sensing ion channels in the mouse anterior pituitary.Computational Tools for Interpreting Ion Channel pH-Dependence.ENaCs and ASICs as therapeutic targets.Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition.Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism.Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.Potential cation and H+ binding sites in acid sensing ion channel-1.Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell culturesDiarylamidines: high potency inhibitors of acid-sensing ion channels.Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel.Identification of protein domains that control proton and calcium sensitivity of ASIC1a.Conformational changes associated with proton-dependent gating of ASIC1a.Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.Acid-sensing ion channels in pathological conditions.The zebrafish as a model for nociception studies.Acid-sensing ion channels under hypoxia.Regulating Factors in Acid-Sensing Ion Channel 1a Function.The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels.Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block.Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells.High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra.Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.An acid-sensing ion channel from shark (Squalus acanthias) mediates transient and sustained responses to protons.Acid-sensing ion channels in neurones of the rat suprachiasmatic nucleus.Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons.
P2860
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P2860
Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Identification of the Ca2+ blo ...... mplications for channel gating
@ast
Identification of the Ca2+ blo ...... mplications for channel gating
@en
type
label
Identification of the Ca2+ blo ...... mplications for channel gating
@ast
Identification of the Ca2+ blo ...... mplications for channel gating
@en
prefLabel
Identification of the Ca2+ blo ...... mplications for channel gating
@ast
Identification of the Ca2+ blo ...... mplications for channel gating
@en
P2860
P356
P1476
Identification of the Ca2+ blo ...... mplications for channel gating
@en
P2093
Elena Babini
Martin Paukert
P2860
P304
P356
10.1085/JGP.200308973
P577
2004-10-01T00:00:00Z