A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation.
about
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis.Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants.The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivationTime-dependent CYP inhibition.Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole.In vitro approaches to investigate mechanism-based inactivation of CYP enzymes.Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment.The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo.Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.Application of mechanism-based CYP inhibition for predicting drug-drug interactions.Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.Metabolic-based drug-drug interactions prediction, recent approaches for risk assessment along drug development.The generation, detection, and effects of reactive drug metabolites.Exploring concepts of in vitro time-dependent CYP inhibition assays.Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin.Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling.The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates.Structure-based prediction of the nonspecific binding of drugs to hepatic microsomes.IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4.Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).
P2860
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P2860
A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@ast
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@en
type
label
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@ast
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@en
prefLabel
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@ast
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@en
P2093
P1476
A critical evaluation of the e ...... n vitro-in vivo extrapolation.
@en
P2093
Bloomer JC
Ghanbari F
Lennard MS
Rostami-Hodjegan A
Rowland-Yeo K
P304
P356
10.2174/138920006776359293
P407
P577
2006-04-01T00:00:00Z