Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwaySIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.Biochemical effects of SIRT1 activatorsEmerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disordersSirtuin 1 and sirtuin 3: physiological modulators of metabolismThe molecular clock as a metabolic rheostatTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?The role of mammalian sirtuins in the regulation of metabolism, aging, and longevityModelling age-related metabolic disorders in the mouseSirtuins in epigenetic regulationPancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of HyperglycemiaSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsSirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patientsMammalian sirtuins: biological insights and disease relevanceIsonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans.A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.Optimal therapy of type 2 diabetes: a controversial challengeRenal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytesDownregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanismsSirtuins: guardians of mammalian healthspan.Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala)"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and agingThe NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control.NAD+ and sirtuins in aging and disease.Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.The aging stress response.Dietary energy balance modulates ovarian cancer progression and metastasis.Calorie restriction and cancer prevention: a mechanistic perspective.Energy balance, host-related factors, and cancer progression.Chromatin remodeling, DNA damage repair and aging.Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in humanPhytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models.The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion.Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiaeThe NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importanceDissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis.Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
P2860
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P2860
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@ast
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@en
type
label
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@ast
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@en
prefLabel
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@ast
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@en
P2093
P2860
P921
P1433
P1476
Age-associated loss of Sirt1-m ...... t1-overexpressing (BESTO) mice
@en
P2093
Akiko Satoh
Kathryn F Mills
Kathryn Moynihan Ramsey
Shin-Ichiro Imai
P2860
P356
10.1111/J.1474-9726.2007.00355.X
P577
2007-11-14T00:00:00Z