Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
about
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesisTpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondiiTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerTpl2 knockout keratinocytes have increased biomarkers for invasion and metastasisRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceAccelerated thymocyte maturation in IL-12Rβ2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelinationAblation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitisPI3Ks in lymphocyte signaling and developmentGenetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury.In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression.Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function.TPL2 kinase is a suppressor of lung carcinogenesisIκB kinase regulation of the TPL-2/ERK MAPK pathway.Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.
P2860
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P2860
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@ast
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@en
type
label
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@ast
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@en
prefLabel
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@ast
Tpl2 and ERK transduce antipro ...... hronically stimulated T cells.
@en
P2093
P2860
P356
P1476
Tpl2 and ERK transduce antipro ...... chronically stimulated T cells
@en
P2093
Andrew N Margioris
Ariadne Androulidaki
Katerina Vaporidi
Philip N Tsichlis
Vassiliki Zacharioudaki
Yuri Sykulev
P2860
P304
P356
10.1073/PNAS.0708381104
P407
P577
2008-02-19T00:00:00Z