Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
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Structure-Function analysis of the CTLA-4 interaction with PP2ACTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsMultiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesA bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetesUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingCTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.Checkpoint inhibitors in hematological malignanciesTyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus.The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetesSystemic lupus erythematosus: from genes to organ damage.Viewpoint: therapeutic implications of CTLA-4 compartmentalization.T-cell costimulatory pathways in allograft rejection and tolerance.Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cellsPaths to understanding the genetic basis of autoimmune disease.Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationTpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.Balancing co-stimulation and inhibition with BTLA and HVEM.Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyDynamic regulation of T-cell costimulation through TCR-CD28 microclusters.Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyConfusing signals: recent progress in CTLA-4 biologyPP2A as a master regulator of the cell cycle.Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity.Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation.Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.TCR subunit specificity of CTLA-4-mediated signaling.In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection.PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.Checkpoint Inhibitors: Applications for Autoimmunity.CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.Phosphorylation of CTLA-4CTLA-4 lacking the cytoplasmic domain costimulates IL-2 production in T-cell hybridomasCompetition and cooperation: Signal transduction by CD28 and CTLA-4
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P2860
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@ast
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@en
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@nl
type
label
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@ast
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@en
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@nl
prefLabel
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@ast
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@en
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@nl
P2093
P1476
Inhibition of CTLA-4 function ...... erine/threonine phosphatase 2A
@en
P2093
Beatriz M Carreno
Estelle Bettelli
Joaquín Madrenas
Lalitha Vijayakrishnan
Miren L Baroja
Peter J Darlington
Thu A Chau
Vijay K Kuchroo
Vincent Ling
P304
P356
10.4049/JIMMUNOL.168.10.5070
P407
P50
P577
2002-05-15T00:00:00Z