Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.
about
Interferon-gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritisThe relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse modelThe genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genesRheumatoid arthritis viewed using a headache paradigm.Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and menDifferential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-kappaB binding activity and TNF-alpha secretion of T cellsInduction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomeraseStructure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritisDesign of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritisInduction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritisTransgenic mouse models of rheumatoid arthritis.Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis.HLA class II transgenic mice: models of the human CD4+ T-cell immune response.The genetic and immunopathological processes underlying collagen-induced arthritis.Transgenic models of autoimmune disease.Humanized mice as a model for rheumatoid arthritis.Mice lacking all conventional MHC class II genes.Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory DiseasesHumanized animal models for autoimmune diseases.MHC class II proteins and disease: a structural perspective.Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic miceSynthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones.Comparative analysis of collagen type II-specific immune responses during development of collagen-induced arthritis in two B10 mouse strains.The role of collagen antibodies in mediating arthritis.Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis.Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells.Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases.The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T-cell activation.T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic miceAssociation analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against α(1)-adrenergic receptors in Chinese patients with essential hypertension.A triple altered collagen II peptide with consecutive substitutions of TCR contacting residues inhibits collagen-induced arthritis.Citrullination of self-proteins and autoimmunity.Prediction of collagen stability from amino acid sequence.Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor.Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues.Complement in the Initiation and Evolution of Rheumatoid Arthritis.
P2860
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P2860
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@ast
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@en
type
label
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@ast
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@en
prefLabel
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@ast
Definition of MHC and T cell r ...... and human CD4 transgenic mice.
@en
P2093
P2860
P356
P1476
Definition of MHC and T cell r ...... and human CD4 transgenic mice
@en
P2093
A Svejgaard
C B Andersen
E C Andersson
G S McDevitt
H Jacobsen
J B Rothbard
L S Madsen
R Holmdahl
P2860
P304
P356
10.1073/PNAS.95.13.7574
P407
P577
1998-06-01T00:00:00Z