Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha10101,beta10401) transgenic mice.

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http://www.wikidata.org/entity/Q36301274

Q36301274

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Cognate peptide-receptor ligand mapping by directed phage display.Human leukocyte Antigen-DM polymorphisms in autoimmune diseases T cell epitopes and post-translationally modified epitopes in type 1 diabetes T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms.Dendritic cell mediated delivery of plasmid DNA encoding LAMP/HIV-1 Gag fusion immunogen enhances T cell epitope responses in HLA DR4 transgenic mice HLA class II transgenic mice as models of human diseases.HLA class II transgenic mice: models of the human CD4+ T-cell immune response.Genetic susceptibility factors of Type 1 diabetes in Asians.DR, DQ, and you: MHC alleles and autoimmunity.T-cell tolerance and autoimmune diabetes.Transgenic models of autoimmune disease.Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.Humanized animal models for autoimmune diseases.T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice.Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.HLA transgenic mice as humanized mouse models of disease and immunity.Autoreactive T cells in a partially humanized murine model of T1D.Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.T cell response pattern to glutamic acid decarboxylase 65 (GAD65) peptides of newly diagnosed type 1 diabetic patients sharing susceptible HLA haplotypes.T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles.TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes Epitopes of the NS3 protein of hepatitis C virus: recognition in HLA-DR4 transgenic mice.Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.Review of the potential health impact of β-casomorphins and related peptides Identification of autoantigen epitopes in MHC class II transgenic mice.Inter-molecular epitope spreading does not lead to extension of autoimmunity beyond target tissue in autoimmune glomerulonephritis

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P2860

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha10101,beta10401) transgenic mice.

Item

http://www.wikidata.org/entity/Q36301274

description

1997 nî lūn-bûn

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1997年の論文

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1997年学术文章

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1997年学术文章

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1997年学术文章

@zh-hans

1997年学术文章

@zh-my

1997年学术文章

@zh-sg

1997年學術文章

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1997年學術文章

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1997年學術文章

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name

Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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type

Item

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Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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Identification of immunodomina ...... 1,beta1*0401) transgenic mice.

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P1476

Identification of immunodomina ...... 01,beta1*0401) transgenic mice

@en

P2093

D Wherrett

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E Kim

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G Sonderstrup-McDevitt

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L Fugger

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S D Patel

http://www.w3.org/2001/XMLSchema#string

T T Chen

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P2860

Mice lacking MHC class II molecules

Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases

Promiscuous and allele-specific anchors in HLA-DR-binding peptides.

MHC class-II molecules and autoimmunity.

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

P304

8082-8087

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scholarly article

P356

10.1073/PNAS.94.15.8082

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English

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P478

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Mauro Congia

Andrew P Cope

P577

1997-07-01T00:00:00Z

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P5875

241200204

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9223318

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P932

21560

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Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

about

P2860

P2860

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha10101,beta10401) transgenic mice.

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha10101,beta10401) transgenic mice.