Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.
about
Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3K/Akt2 Signaling Pathway in Skeletal Muscle of KKAy Mice.Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytesHepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes MellitusBMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humansMetabolic master regulators: sharing information among multiple systems.Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulationBrain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy.A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance.Hepatoprotective potential of isoquercitrin against type 2 diabetes-induced hepatic injury in rats.Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei
P2860
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P2860
Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@ast
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@en
type
label
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@ast
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@en
prefLabel
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@ast
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@en
P2860
P1433
P1476
Insulin signalling in hepatocy ...... reversal by PKC-ι inhibitors.
@en
P2093
P2860
P2888
P304
P356
10.1007/S00125-012-2477-5
P577
2012-02-15T00:00:00Z