A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
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The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cellsInduction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibitionInhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosisHigh affinity binding sites for the Wilms' tumour suppressor protein WT1DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemiaThe Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cellsThe zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene.FGFR1 and WT1 are markers of human prostate cancer progression.Antagonism of WT1 activity by protein self-association.Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferationThe Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.Molecular genetics of chromosome translocations involving EWS and related family members.Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene productWilms' tumor suppressor gene (WT1) suppresses apoptosis by transcriptionally downregulating BAX expression in immature rat granulosa cells.Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms.Insights into the physiological role of WT1 from studies of genetically modified mice.The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histologyLeydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice.Expression and function of the leucine zipper protein Par-4 in apoptosis.A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiationModification of EWS/WT1 functional properties by phosphorylationSp1 is a critical regulator of the Wilms' tumor-1 gene.New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional targetRNA binding by the Wilms tumor suppressor zinc finger proteins.WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product.DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control.Activation of the WT1 tumor suppressor gene promoter by Pea3.The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development.WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma.WT1 regulates angiogenesis in Ewing SarcomaDistinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia.Wilms' tumor: a paradigm for insights into development and cancer.Transcriptional activation of c-myc proto-oncogene by WT1 protein.Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter.
P2860
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P2860
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@ast
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@en
type
label
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@ast
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@en
prefLabel
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@ast
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@en
P2093
P2860
P356
P1476
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.19.8896
P407
P577
1993-10-01T00:00:00Z