Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. - Wikidata - wikimedia - TriplyDB

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

http://www.wikidata.org/entity/Q36563979

about

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.Rescue from replication stress during mitosis.Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae When Genome Maintenance Goes Badly Awry.CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.FANCD2 limits replication stress and genome instability in cells lacking BRCA2.Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction.MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive and negative Ustilago maydis.BRCA1 gene: function and deficiency.Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.Copper-Alkyne Complexation Responsible for the Nucleolar Localization of Quadruplex Nucleic Acid Drugs Labeled by Click Reactions.TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.Modeling Therapy Resistance in BRCA1/2-Mutant Cancers.Mutant ATRX: uncovering a new therapeutic target for glioma.Extended Naphthalene Diimides with Donor/Acceptor Hydrogen-Bonding Properties Targeting G-Quadruplex Nucleic Acids

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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

http://www.wikidata.org/entity/Q36563979

description

2015 nî lūn-bûn

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2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

@en

type

label

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

@ast

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

@en

prefLabel

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

@ast

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

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J.MOLCEL.2015.12.004

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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

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Cecilia Folio

http://www.w3.org/2001/XMLSchema#string

Jutta Zimmer

http://www.w3.org/2001/XMLSchema#string

Kerstin Klare

http://www.w3.org/2001/XMLSchema#string

Kristijan Ramadan

http://www.w3.org/2001/XMLSchema#string

Madalena Tarsounas

http://www.w3.org/2001/XMLSchema#string

Sergey G Kuznetsov

http://www.w3.org/2001/XMLSchema#string

Sophie Badie

http://www.w3.org/2001/XMLSchema#string

Swagata Halder

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of parallel quadruplexes from human telomeric DNA

Telomere maintenance requires the RAD51D recombination/repair protein

Prevalence of quadruplexes in the human genome.

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

Genomic instability--an evolving hallmark of cancer

Quantitative visualization of DNA G-quadruplex structures in human cells

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449-460

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scholarly article

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10.1016/J.MOLCEL.2015.12.004

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3

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61

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Stephen P Jackson

Annamaria Biroccio

Anderson J Ryan

Manuela Tumiati

Eliana M C Tacconi

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2015-12-31T00:00:00Z

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26748828

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