about
Memory in the B-cell compartment: antibody affinity maturationVertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesionsSequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.Visualisation of PCNA monoubiquitination in vivo by single pass spectral imaging FRET microscopy.The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)Antibody diversification and selection in the mature B-cell compartment.The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.Immunoglobulin diversification in DT40: a model for vertebrate DNA damage tolerance.Directed evolution of human scFvs in DT40 cells.RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent ChromiumPrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.Clock-like mutational processes in human somatic cells.Y-family DNA polymerases and their role in tolerance of cellular DNA damage.The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic StabilityAnalysis of DNA replication damage bypass and its role in immunoglobulin repertoire development.The topography of mutational processes in breast cancer genomes.Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutationCellular epigenetic stability and cancer.Competition, collaboration and coordination--determining how cells bypass DNA damage.Translesion DNA synthesis and mutagenesis in eukaryotesContributions of the specialised DNA polymerases to replication of structured DNA.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression.Histone H3.3 is required to maintain replication fork progression after UV damage.Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells.The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory.Role for RAD18 in homologous recombination in DT40 cells.Measurement of diversification in the immunoglobulin light chain gene of DT40 cells.Monitoring I-SceI-induced double-strand break repair in DT40 cells.FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.A rare case of dermatitis herpetiformis requiring parenteral heparin for long-term control.Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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Julian E Sale
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P106
P21
P31
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0000-0002-5031-3780