Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
about
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteinsTelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Substrate-specific inhibition of RecQ helicaseRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceInhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.Mechanistic and biological aspects of helicase action on damaged DNA.New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.Distinct roles of RECQ1 in the maintenance of genomic stability.Deficiency of Bloom syndrome helicase activity is radiomimeticInteractions of DNA helicases with damaged DNA: possible biological consequences.Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.RecQ helicases: suppressors of tumorigenesis and premature aging.Discovering new medicines targeting helicases: challenges and recent progress.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityHelicases - feasible antimalarial drug target for Plasmodium falciparum.Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent.Inhibition of unwinding and ATPase activities of Plasmodium falciparum Dbp5/DDX19 homolog.Expression of Werner and Bloom syndrome genes is differentially regulated by in vitro HIV-1 infection of peripheral blood mononuclear cells.DNA repair and mutagenesis in Werner syndrome.Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.Werner syndrome protein contains three structure-specific DNA binding domains.Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.Plasmodium falciparum DNA helicase 60. dsRNA- and antibody-mediated inhibition of malaria parasite growth and downregulation of its enzyme activities by DNA-interacting compounds.
P2860
Q24292733-B1B1B322-43E5-4193-B85F-752D2F75ECEDQ28116259-65832696-5134-4311-8A99-CF23AD3B9E3EQ28362135-76EAFD44-AC5C-4CDA-9457-F71DC95E19FEQ28771762-1E237DA3-5E2C-4ED8-B354-F33AB01155C3Q33230386-08F243DD-BE1D-4ABC-92C6-0C174956160FQ33391858-EAF95BAD-6F86-48AC-B687-4DB8CC025E5BQ33614603-B12E31EB-199E-4AF6-A940-72F15A9FEB1DQ33652585-A0C68F4B-DFD1-413B-AE80-173C75A7D53EQ33684409-37B1CA39-2F4E-456B-A7B8-92A9272CFA6FQ33937549-25040E98-175E-4951-990E-9388F1EAE7B2Q34011942-A98E4243-8825-4B50-AD3C-3B728572AB6CQ34313126-53C7657E-3B24-425A-860A-58AD98E11B37Q35044119-7AE4762C-F999-424D-9869-58BD87557665Q35131087-0E450427-F3EF-49EF-A578-8B7E03653113Q35152970-7957FC7A-FC9B-48EB-B257-D72A9F6252BAQ35592783-2E52A3AB-CBB4-4224-9AE6-6F9EB310A44CQ36573932-9965C288-C80B-418A-995D-761DA61BCD26Q36933788-F167D2C4-E120-4CB5-B445-69D0015F989DQ37299533-6379AAC3-4B15-496C-8D6D-7A1DB5BD6763Q37392700-542001EA-31A3-4444-8D17-3310C9CFB28EQ38352253-82B399DA-3A45-4B41-9F94-C40FF547A73EQ38636026-E0631E97-E0F2-4EAA-BC36-7E1CF6890D3FQ38914981-AC700127-242F-4D5F-AF76-ED3CDA95CB4AQ40762854-1F02C201-DB49-41B8-9F18-0056B1A8368BQ42001099-008D0F7B-A0A7-4A53-B0BA-9F47641C492FQ44611028-09CF4EA1-3D58-4A8F-93AF-27D25F394836Q47332864-2D43F817-C244-4869-9F93-913FF54707CFQ48033564-69EACA96-A4E4-4C12-938E-AC773F70933E
P2860
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@ast
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en-gb
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@nl
type
label
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@ast
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en-gb
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@nl
prefLabel
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@ast
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en-gb
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@nl
P2093
P2860
P921
P356
P1476
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
@en
P2093
P2860
P304
P356
10.1093/NAR/28.12.2420
P407
P577
2000-06-15T00:00:00Z