Clusters of point mutations are found exclusively around rearranged antibody variable genes
about
Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely relatedAltered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Somatic hypermutation introduces insertions and deletions into immunoglobulin V genesIncreased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinAltered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2Molecular basis for expression of the A48 regulatory idiotope on antibodies encoded by immunoglobulin variable-region genes from various families.Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenIdentification of mutant monoclonal antibodies with increased antigen bindingAn immunoglobulin mutator that targets G.C base pairs.Altered spectra of hypermutation in DNA repair-deficient mice.A new class of errant DNA polymerases provides candidates for somatic hypermutation.The reverse transcriptase model of somatic hypermutationNeonatal immunity and somatic mutation.Genome-wide somatic hypermutation.Analyses of chicken immunoglobulin light chain cDNA clones indicate a few germline V lambda genes and allotypes of the C lambda locusSilent development of memory progenitor B cellsRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regionsIdentity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice.Emerging links between hypermutation of antibody genes and DNA polymerases.High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.Generation and characterization of chicken-sourced single-chain variable fragments (scFvs) against porcine interferon-gamma (pIFN-γ).c-myc hypermutation in Burkitt's lymphoma.Rearrangements of DNA mediated by terminal transferase.DNA-cytosine deaminases: from antibody maturation to antiviral defense.Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom.Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-mu heavy chain gene.Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.Somatic diversification of immunoglobulins.Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.Multiple VH gene segments encode murine antistreptococcal antibodiesDiversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family.Analysis of somatic mutations in kappa transgenes.Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.
P2860
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P2860
Clusters of point mutations are found exclusively around rearranged antibody variable genes
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
1983年论文
@zh
1983年论文
@zh-cn
name
Clusters of point mutations ar ...... ranged antibody variable genes
@ast
Clusters of point mutations ar ...... ranged antibody variable genes
@en
type
label
Clusters of point mutations ar ...... ranged antibody variable genes
@ast
Clusters of point mutations ar ...... ranged antibody variable genes
@en
prefLabel
Clusters of point mutations ar ...... ranged antibody variable genes
@ast
Clusters of point mutations ar ...... ranged antibody variable genes
@en
P2860
P356
P1476
Clusters of point mutations ar ...... ranged antibody variable genes
@en
P2093
D F Bogenhagen
P J Gearhart
P2860
P304
P356
10.1073/PNAS.80.11.3439
P407
P577
1983-06-01T00:00:00Z