Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. - Wikidata - wikimedia - TriplyDB

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

http://www.wikidata.org/entity/Q36602188

about

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy Ran signaling in melanoma: implications for the development of alternative therapeutic strategies.Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression Cells and Stripes: A novel quantitative photo-manipulation technique.Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response.Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation.The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.Premature aging/senescence in cancer cells facing therapy: good or bad?Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe.Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Cell Cycle Regulation and Melanoma.To clear, or not to clear (senescent cells)? That is the question.AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment.Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization.Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses.MDM2 Antagonists Counteract Drug-Induced DNA Damage.MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21.Pathways from senescence to melanoma: focus on MITF sumoylation.The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis.DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer.Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.p53 accumulation following cytokinesis failure in the absence of caspase-2

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Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

http://www.wikidata.org/entity/Q36602188

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... this drug-induced senescence.

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Targeting aurora kinases limit ...... s this drug-induced senescence

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Ann Richmond

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Anna E Vilgelm

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Jeffery A Ecsedy

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Jeffery A Sosman

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Katayoun I Amiri

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Mark C Kelley

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Oriana E Hawkins

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Ryan C Splittgerber

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Sara Kantrow

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Tammy Sobolik

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P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

M-1/M-2 macrophages and the Th1/Th2 paradigm

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

From polyploidy to aneuploidy, genome instability and cancer

Chemokine signaling via the CXCR2 receptor reinforces senescence

Signals from within: the DNA-damage-induced NF-kappaB response

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

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149-166

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10.1002/EMMM.201201378

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1

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5

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Sarah Palmer Short

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233770543

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23180582

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