Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
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Telomere and Telomerase Therapeutics in CancerPutative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes.Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Mechanistic insight into ligand binding to G-quadruplex DNASide-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signallingExploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Structural insights into G-quadruplexes: towards new anticancer drugs.An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteinsIdentification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesRHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT).Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiaeTelomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteinsElevated levels of G-quadruplex formation in human stomach and liver cancer tissues.G-quadruplexes: from guanine gels to chemotherapeuticsA newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.Telomerase and its potential for therapeutic intervention.MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN/66-1 in hormone-insensitive PC-3 prostate cancer cells and tumours.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceA hitchhiker's guide to G-quadruplex ligands.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsA G-quadruplex stabilizer induces M-phase cell cycle arrestPancreatic cancer stem cells: new insights and perspectives.The application of DNA and RNA G-quadruplexes to therapeutic medicines.G-quadruplexes: targets and tools in anticancer drug design.G-quadruplexes as potential therapeutic targets for embryonal tumors.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?Targeting G-quadruplex structures with extrinsic fluorogenic dyes: promising fluorescence sensors.Pyrene-imidazolium complexed graphene for the selective fluorescent detection of G-quadruplex forming DNA.Seven essential questions on G-quadruplexes.Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifsG-Quadruplex binding enantiomers show chiral selective interactions with human telomere.Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.Telomerase and drug resistance in cancer.Native electrospray mass spectrometry of DNA G-quadruplexes in potassium solution.Loop flexibility in human telomeric quadruplex small-molecule complexes.
P2860
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P2860
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@ast
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@en
type
label
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@ast
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@en
prefLabel
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@ast
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@en
P2093
P2860
P356
P1476
Telomere uncapping by the G-qu ...... stem cell targeting mechanism.
@en
P2093
A M Burger
J C Cookson
M F G Stevens
R B Gartenhaus
P2860
P2888
P304
P356
10.1038/SJ.BJC.6603691
P407
P577
2007-04-03T00:00:00Z