Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
about
DNA Polymerase Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Perspective: Defining and quantifying the role of dynamics in enzyme catalysisEffect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W.Elucidation of the conformational free energy landscape in H.pylori LuxS and its implications to catalysisStructural basis for the D-stereoselectivity of human DNA polymerase β.The reopening rate of the fingers domain is a determinant of base selectivity for RB69 DNA polymerase.Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issuesMultiscale modeling of biological functions.Prechemistry versus preorganization in DNA replication fidelity.An abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity.The associative nature of adenylyl transfer catalyzed by T4 DNA ligase.On the relationship between folding and chemical landscapes in enzyme catalysisRole of induced fit in enzyme specificity: a molecular forward/reverse switch.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Coupled motions in enzyme catalysis.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids.Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation.Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading.Kinetics and thermodynamics of exonuclease-deficient DNA polymerases.Renormalizing SMD: the renormalization approach and its use in long time simulations and accelerated PMF calculations of macromolecules.A binding free energy decomposition approach for accurate calculations of the fidelity of DNA polymerases.A computational study of the hydrolysis of dGTP analogues with halomethylene-modified leaving groups in solution: implications for the mechanism of DNA polymerases.Multiscale simulations of protein landscapes: using coarse-grained models as reference potentials to full explicit models.Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
P2860
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P2860
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@ast
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@en
type
label
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@ast
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@en
prefLabel
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@ast
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@en
P2093
P2860
P356
P1433
P1476
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta
@en
P2093
Myron F Goodman
Samuel H Wilson
William A Beard
P2860
P304
P356
10.1002/PROT.21668
P407
P577
2008-01-01T00:00:00Z