A century-old debate on protein aggregation and neurodegeneration enters the clinic.
about
Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's diseaseAbeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in DrosophilaMutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementiaα-Synuclein occurs physiologically as a helically folded tetramer that resists aggregationSystematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activitiesElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesMitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Mitochondrial dysfunction and oxidative stress in Parkinson's diseaseGenome-wide screen for modifiers of ataxin-3 neurodegeneration in DrosophilaNiclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibitionStabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formationDynamic -Helix Structure of Micelle-bound Human AmylinSystematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's diseaseScreening for toxic amyloid in yeast exemplifies the role of alternative pathway responsible for cytotoxicityInhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesNeurotoxicity of prion peptides mimicking the central domain of the cellular prion proteinAβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's diseaseExploring the aggregation propensity of γS-crystallin protein variants using two-dimensional spectroscopic toolsBiophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Revealing different aggregation pathways of amyloidogenic proteins by ultrasound velocimetry.Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathyMutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.Abeta42 mutants with different aggregation profiles induce distinct pathologies in DrosophilaHigh throughput screening for neurodegeneration and complex disease phenotypes.Finite size effects in simulations of protein aggregation.A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A.17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagyRibosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease.Regulation of amyloid precursor protein processing by the Beclin 1 complexAmyloid structure and assembly: insights from scanning transmission electron microscopy.Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body DementiaStructure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disordersTransgenic Drosophila models of Alzheimer's disease and tauopathiesPyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.
P2860
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P2860
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@ast
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@en
type
label
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@ast
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@en
prefLabel
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@ast
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@en
P2860
P356
P1433
P1476
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
@en
P2093
Peter T Lansbury
P2860
P2888
P304
P356
10.1038/NATURE05290
P407
P577
2006-10-01T00:00:00Z