Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.
about
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingDifferential role of RB in response to UV and IR damage.Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein bindingAberrant regulation of survivin by the RB/E2F family of proteinsAdenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-regionEssential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexdeltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivoThe p53 pathway and apoptosis.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexApoptosis in cancer.Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.Role of the E1A Rb-binding domain in repression of the NF-kappa B-dependent defense against tumor necrosis factor-alphaAdenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulationGeneration and characterization of Smac/DIABLO-deficient mice.BRCA1 and prostate cancer.Normal p53 function in primary cells deficient for Siah genes.p400 is required for E1A to promote apoptosis.Adenovirus infection of primary malignant lymphoid cells.Simian virus 40 large T antigen and two independent T-antigen segments sensitize cells to apoptosis following genotoxic damagePML is induced by oncogenic ras and promotes premature senescenceE1A signaling to p53 involves the p19(ARF) tumor suppressor.Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO ModificationpRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Adenovirus E1A targets p400 to induce the cellular oncoprotein MycDefects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer.Oncogene-dependent apoptosis is mediated by caspase-9.RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insultThe anti-tumor activity of E1A and its implications in cancer therapy.MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells.E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.Induction of p53-independent apoptosis by simian virus 40 small t antigen.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1aDifferential regulation of apoptotic genes by Rb in human versus mouse cells.Direct coupling of the cell cycle and cell death machinery by E2F.
P2860
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P2860
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Selective induction of p53 and ...... bind the RB-related proteins.
@ast
Selective induction of p53 and ...... bind the RB-related proteins.
@en
type
label
Selective induction of p53 and ...... bind the RB-related proteins.
@ast
Selective induction of p53 and ...... bind the RB-related proteins.
@en
prefLabel
Selective induction of p53 and ...... bind the RB-related proteins.
@ast
Selective induction of p53 and ...... bind the RB-related proteins.
@en
P2860
P356
P1476
Selective induction of p53 and ...... bind the RB-related proteins.
@en
P2093
A V Samuelson
P2860
P304
12094-12099
P356
10.1073/PNAS.94.22.12094
P407
P577
1997-10-01T00:00:00Z