Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.
about
Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteinsInitial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridgeThe initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerp14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasisGenes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formationDelta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivoMammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sitesGenetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitaliaGPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesisMice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathyDysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokinesEpidermal RAF prevents allergic skin diseaseC-terminal Src kinase controls development and maintenance of mouse squamous epithelia.Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient micePhenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cellsEvolutionary considerations in relating oligosaccharide diversity to biological function.Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.Genetic analysis of cytoprotective functions supported by graded expression of Keap1Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p.Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceEssential role for the TRF2 telomere protein in adult skin homeostasisSimulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins.The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin.Glycosyl phosphatidylinositol-anchored proteins in chemosensory signaling: antisense manipulation of Paramecium tetraurelia PIG-A gene expression.Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.Disruption of eyelid and cornea morphogenesis by epithelial β-catenin gain-of-function.Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury.Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.Epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina.
P2860
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P2860
Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Tissue-specific knockout of th ...... proteins in skin development.
@ast
Tissue-specific knockout of th ...... proteins in skin development.
@en
type
label
Tissue-specific knockout of th ...... proteins in skin development.
@ast
Tissue-specific knockout of th ...... proteins in skin development.
@en
prefLabel
Tissue-specific knockout of th ...... proteins in skin development.
@ast
Tissue-specific knockout of th ...... proteins in skin development.
@en
P2093
P2860
P356
P1476
Tissue-specific knockout of th ...... d proteins in skin development
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.14.7400
P407
P577
1997-07-01T00:00:00Z