AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
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Emerging gene therapies for retinal degenerationsAAV-mediated gene therapy in mouse models of recessive retinal degenerationRestoration of vision in the pde6β-deficient dog, a large animal model of rod-cone dystrophyReview: the history and role of naturally occurring mouse models with Pde6b mutationsCaspase inhibition with XIAP as an adjunct to AAV vector gene-replacement therapy: improving efficacy and prolonging the treatment windowAAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsiaMouse model resources for vision research.Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutationsDifferential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosaSelf-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse.Rod Outer Segment Development Influences AAV-Mediated Photoreceptor Transduction After Subretinal Injection.Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency.Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease.Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa.Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.Vector platforms for gene therapy of inherited retinopathies.Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosisA single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degenerationGeneral pathophysiology in retinal degeneration.Gene therapy using self-complementary Y733F capsid mutant AAV2/8 restores vision in a model of early onset Leber congenital amaurosisC1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa.Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsiaTrans-Corneal Subretinal Injection in Mice and Its Effect on the Function and Morphology of the Retina.Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept.Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 miceAAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy.Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration.Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosaAAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human DiseaseTherapeutic margins in a novel preclinical model of retinitis pigmentosa.Novel mutations in PDE6B causing human retinitis pigmentosaAdvances in Gene Therapy for Diseases of the Eye.Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors
P2860
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P2860
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@ast
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@en
type
label
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@ast
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@en
prefLabel
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@ast
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@en
P2093
P2860
P356
P1476
AAV-mediated gene therapy for ...... a recessive PDEbeta mutation.
@en
P2093
Ashok Kumar
Astra Dinculescu
Jeffrey H Boatright
Ji-Jing Pang
Norman L Hawes
Qiuhong Li
Sanford L Boye
P2860
P304
P356
10.1167/IOVS.07-1622
P407
P577
2008-06-27T00:00:00Z