Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.
about
Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming abilityEvi-1 transforming and repressor activities are mediated by CtBP co-repressor proteinsSequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZFPbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsStaf, a novel zinc finger protein that activates the RNA polymerase III promoter of the selenocysteine tRNA geneGfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressorAn emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous systemIdentification of binding sites of EVI1 in mammalian cellsSMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cellsZinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for bindingThe Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteinsMutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic ThrombocytopeniaRUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA.The KLHL1-antisense transcript ( KLHL1AS) is evolutionarily conserved.Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defectsEcotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.Expression of the zinc finger gene EVI-1 in ovarian and other cancers.The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing proteinTargeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arraysPathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.Evi-1 as a critical regulator of leukemic cells.PRDM proteins: important players in differentiation and disease.Protein-DNA binding: complexities and multi-protein codes.EVI1 promotes tumor growth via transcriptional repression of MS4A3.Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III.Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity.Review: Aberrant EVI1 expression in acute myeloid leukaemia.Functions of Prdm16 in thermogenic fat cells.EVI1 induces myelodysplastic syndrome in mice.Stereochemical basis of DNA recognition by Zn fingers.Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence.EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia.
P2860
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P2860
Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@ast
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@en
type
label
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@ast
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@en
prefLabel
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@ast
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@en
P2093
P2860
P356
P1476
Four of the seven zinc fingers ...... ng to GA(C/T)AAGA(T/C)AAGATAA.
@en
P2093
P2860
P304
P356
10.1128/MCB.13.7.4291
P407
P577
1993-07-01T00:00:00Z