High-fat diets cause insulin resistance despite an increase in muscle mitochondria
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Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese MiceOmega-3 Fatty Acids and Skeletal Muscle HealthIn obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidationLong-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondriaActivity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese miceTwo weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type miceEpinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat dietChanges in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF ratsAltered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercisePGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM).Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistancePioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes.Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF ratsLocal non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes.Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function.Skeletal muscle NAMPT is induced by exercise in humans.Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects.Mitochondrial response to nutrient availability and its role in metabolic disease.Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation.Metabolic syndrome: from epidemiology to systems biology.The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesisDeficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance.Increased oxidative phosphorylation in response to acute and chronic DNA damage.Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity.Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.Therapies in inborn errors of oxidative metabolism.Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscleHigh fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance.Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin miceIncreasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans.Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosisPeroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heartMangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets.High fatty acid availability after exercise alters the regulation of muscle lipid metabolismMitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice.
P2860
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P2860
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@ast
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@en
type
label
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@ast
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@en
prefLabel
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@ast
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@en
P2093
P2860
P356
P1476
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
@en
P2093
Chad R Hancock
David C Wright
Dong-Ho Han
John O Holloszy
Shin Terada
Toshihiro Yasuda
P2860
P304
P356
10.1073/PNAS.0802057105
P407
P577
2008-05-28T00:00:00Z