Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsA cellular repressor of E1A-stimulated genes that inhibits activation by E2FHomologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsRBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteinsDifferential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding proteinStructure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressorStructural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoproteinp300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigenCell-specific modulation of papovavirus replication by tumor suppressor protein p53The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.Role of the LXCXE binding site in Rb functionAdenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.Mutational analysis of the conserved region 2 site of adenovirus E1A and its effect on binding to the retinoblastoma gene product: use of the "double-tagging" assayE2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude miceInduction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisCoevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.Cell polarity proteins: common targets for tumorigenic human viruses.Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein.Transcriptional repression and growth suppression by the p107 pocket protein.Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthIndependent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.Identification of distinct roles for separate E1A domains in disruption of E2F complexes.Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin.Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth.Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus.Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.
P2860
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P2860
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@ast
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@en
type
label
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@ast
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@en
prefLabel
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@ast
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@en
P2093
P2860
P1433
P1476
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
@en
P2093
P2860
P304
P407
P577
1992-07-01T00:00:00Z