Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.
about
A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineInterferon regulatory factor 4 contributes to transformation of v-Rel-expressing fibroblastsComparative analyses of immunoglobulin genes: surprises and portents.Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genesDevelopment of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of fabriciusImmunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1Directed evolution of human scFvs in DT40 cells.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.Pax5--a critical inhibitor of plasma cell fate.MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsE2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification.DNA polymerases in adaptive immunity.Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.RAG-2 expression is not essential for chicken immunoglobulin gene conversion.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.Role for RAD18 in homologous recombination in DT40 cells.Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Aiolos controls gene conversion and cell death in DT40 B cells.Avian B cell development.Immunology. Antibody alterations.Duck antibody responses to keyhole limpet haemocyanin, human immunoglobulin G and the trinitrophenyl hapten. Evidence of affinity maturation.The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A.Applications of Gene Editing in Chickens: A New Era Is on the HorizonBursa of Fabricius
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P2860
Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@ast
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@en
type
label
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@ast
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@en
prefLabel
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@ast
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@en
P2093
P2860
P356
P1476
Ongoing diversification of the ...... n a bursal lymphoma cell line.
@en
P2093
C B Thompson
E H Humphries
L Tjoelker
P2860
P304
P356
10.1128/MCB.10.6.3224
P407
P577
1990-06-01T00:00:00Z