Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.
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Multiple roles of vertebrate REV genes in DNA repair and recombinationA genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repairMouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisRibozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT geneThe BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesisVertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1REV1 and polymerase ζ facilitate homologous recombination repairRole of single-stranded DNA in targeting REV1 to primer terminiFormation and repair of interstrand cross-links in DNADNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.A role for PCNA ubiquitination in immunoglobulin hypermutation.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Visualisation of PCNA monoubiquitination in vivo by single pass spectral imaging FRET microscopy.Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.Cross-link structure affects replication-independent DNA interstrand cross-link repair in mammalian cellsDifferent mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationKinetic basis of nucleotide selection employed by a protein template-dependent DNA polymeraseUsing synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy.Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayDNA polymerases and somatic hypermutation of immunoglobulin genesThe genome of the chicken DT40 bursal lymphoma cell line.Involvement of Rad18 in somatic hypermutationThe critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phaseMechanism of replication-coupled DNA interstrand crosslink repair.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases.Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.DNA deamination in immunity.Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.Does DNA repair occur during somatic hypermutation?Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regionsContribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseDNA repair in antibody somatic hypermutation.Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.DNA polymerases and cancer.Uracil within DNA: an actor of antiviral immunity.
P2860
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P2860
Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
@zh-hant
name
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@en
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@nl
type
label
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@en
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@nl
prefLabel
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@en
Rev1 is essential for DNA dama ...... ion in a vertebrate cell line.
@nl
P2860
P356
P1433
P1476
Rev1 is essential for DNA dama ...... tion in a vertebrate cell line
@en
P2093
Laura J Simpson
P2860
P304
P356
10.1093/EMBOJ/CDG161
P407
P577
2003-04-01T00:00:00Z