Applying mechanisms of chemical toxicity to predict drug safety.
about
Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicityFialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testingUsing chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.In vitro platforms for evaluating liver toxicity.Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.Can 'humanized' mice improve drug development in the 21st century?High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism.Profiling the reactive metabolites of xenobiotics using metabolomic technologiesCytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophileMetabolomic screening and identification of the bioactivation pathways of ritonavirDrug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural featuresCPY3A4-mediated α-hydroxyaldehyde formation in saquinavir metabolism.Factors affecting the development of adverse drug reactions (Review article)Metabolites in safety testing: "MIST" for the clinical pharmacologist.Mechanisms of drug toxicity and relevance to pharmaceutical development.Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance.From known knowns to known unknowns: predicting in vivo drug metabolites.Managing the challenge of chemically reactive metabolites in drug development.Pharmacological mechanism-based drug safety assessment and prediction.Assessment of reactive metabolites in drug-induced liver injury.The generation, detection, and effects of reactive drug metabolites.Practical approaches to resolving reactive metabolite liabilities in early discovery.Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.Detecting reactive drug metabolites for reducing the potential for drug toxicity.Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Metabolism and bioactivation of the tricyclic antidepressant amitriptyline in human liver microsomes and human urine.CYP isoform specificity toward drug metabolism: analysis using common feature hypothesis.Mixed learning algorithms and features ensemble in hepatotoxicity prediction.Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.Metabolism-guided drug designComputational prediction of drug binding and rationalisation of selectivity towards cytochromes P450
P2860
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P2860
Applying mechanisms of chemical toxicity to predict drug safety.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Applying mechanisms of chemical toxicity to predict drug safety.
@ast
Applying mechanisms of chemical toxicity to predict drug safety.
@en
type
label
Applying mechanisms of chemical toxicity to predict drug safety.
@ast
Applying mechanisms of chemical toxicity to predict drug safety.
@en
prefLabel
Applying mechanisms of chemical toxicity to predict drug safety.
@ast
Applying mechanisms of chemical toxicity to predict drug safety.
@en
P356
P1476
Applying mechanisms of chemical toxicity to predict drug safety.
@en
P2093
F Peter Guengerich
James S MacDonald
P304
P356
10.1021/TX600260A
P577
2007-02-16T00:00:00Z