From known knowns to known unknowns: predicting in vivo drug metabolites. - Wikidata - wikimedia - TriplyDB

From known knowns to known unknowns: predicting in vivo drug metabolites.

From known knowns to known unknowns: predicting in vivo drug metabolites.

http://www.wikidata.org/entity/Q37810200

about

Drug Metabolism - From In Vitro to In Vivo, From Simple to Complex: Reflections of the BCPT Nordic Prize 2014 Awardee Advances in structure elucidation of small molecules using mass spectrometry Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.In silico toxicology - non-testing methods.Liquid chromatography/quadrupole time-of-flight mass spectrometry in combination with online hydrogen/deuterium exchange technique for structural elucidation of phase I metabolites of iso-phenylcyclopentylamine in rat bile.Towards polypharmacokinetics: pharmacokinetics of multicomponent drugs and herbal medicines using a metabolomics approach.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions.A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose.

P2860

Q28083049-ED29F0B0-2DEB-4C08-B53D-62F69C8FA8CD Q28743720-F6A87E37-87E3-4A67-8F31-E5439F7B51FE Q34181630-BB32AA00-292F-4AEA-895A-BF46489409D4 Q35084668-52065FBA-95DF-4A6B-A2A2-31C8395BDA5F Q35123312-205CF175-2CE9-40EA-8D27-1C4D3770E02D Q36729102-C19539A7-99BC-4AAD-AB44-A42FBDE72ED8 Q38540503-32EBFE07-6262-4395-9273-FD264B2BDF2E Q39730914-34E96FA0-7DCC-4A52-975F-CE992A61366A Q46751744-D2337542-3C3B-4F74-9B4A-42402D0F3BB4

P2860

From known knowns to known unknowns: predicting in vivo drug metabolites.

http://www.wikidata.org/entity/Q37810200

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on May 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

From known knowns to known unknowns: predicting in vivo drug metabolites.

@en

From known knowns to known unknowns: predicting in vivo drug metabolites.

@nl

type

label

From known knowns to known unknowns: predicting in vivo drug metabolites.

@en

From known knowns to known unknowns: predicting in vivo drug metabolites.

@nl

prefLabel

From known knowns to known unknowns: predicting in vivo drug metabolites.

@en

From known knowns to known unknowns: predicting in vivo drug metabolites.

@nl

P1433

Q37810200-6F077BF4-DF06-450E-B23D-63422D12138A

P1476

Q37810200-35C1084A-BEC8-4CAC-8FB8-FFE33B4BF845

P2093

Q37810200-511EC1E4-D754-46EB-A327-F8120207E154

Q37810200-75A1F7A9-1B8C-49E4-8FE3-B3D76944AFC7

Q37810200-90B7E44D-F24D-4735-92E2-FB8A15163E19

Q37810200-A0B30152-93E7-4F8E-852D-8B54CB9C5B71

P2860

Q37810200-005570F3-5824-43C2-9B31-AFD9B97BA295

Q37810200-00C994C2-B4B1-43CA-A55B-39EE65E1CFAF

Q37810200-039F09FC-5ED5-4C7B-9C4D-A3AA14C027F6

Q37810200-04699C99-9466-4814-919A-9AC75D26A6AF

Q37810200-048315D4-7021-4F2F-9282-669F772F7A09

Q37810200-06404E92-5445-4B11-BBA6-A939D4156E6C

Q37810200-081D214F-E6B1-4545-8524-94C485B8ABBC

Q37810200-0AC59C17-3461-411A-9AED-66EEDBFB0ED4

Q37810200-0DD0199B-6672-448E-B9DD-8FE7DF98F883

Q37810200-0FEE0C82-0A5F-4F4C-AB1E-A77FB5855044

P304

Q37810200-AC9861AD-54F9-4C53-B3DD-CFAF56F2574E

P31

Q37810200-22E379F8-DA46-450C-A32D-BD27518ED762

P356

Q37810200-D799BE53-442C-4322-A3C9-6586B8E51041

P433

Q37810200-77F0FB18-C0B1-465F-870C-91B00A83C564

P478

Q37810200-CE96DA21-F25D-46C9-A1E8-0FD2BF15061F

P50

Q37810200-6B40D6C1-B1E3-4809-AF7C-39B3A011AD21

P577

Q37810200-1F332796-0C29-4CED-8637-BAF64E09B552

P5875

Q37810200-05DF4C08-8653-4EE8-A124-D20BFF35556C

P698

Q37810200-2CADD4F0-5977-4472-98A6-8FB01B27F1A9

P356

P1433

P1476

From known knowns to known unknowns: predicting in vivo drug metabolites.

@en

P2093

Ari Tolonen

http://www.w3.org/2001/XMLSchema#string

Hannu Raunio

http://www.w3.org/2001/XMLSchema#string

Olavi Pelkonen

http://www.w3.org/2001/XMLSchema#string

Timo Korjamo

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

LC/MS applications in drug development

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry

Analytical tools and approaches for metabolite identification in early drug discovery.

Advantages of atmospheric pressure photoionization mass spectrometry in support of drug discovery.

Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

P304

393-414

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.4155/BIO.09.32

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

1

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47810576

http://www.w3.org/2001/XMLSchema#string

P698

21083174

http://www.w3.org/2001/XMLSchema#string