Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
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The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type foldReduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationThe crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition.Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.Inter-α-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in ΔF508 mice.The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiationProteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.Increased matriptase zymogen activation in inflammatory skin disorders.Urinary prostasin excretion is associated with adiposity in nonhypertensive African-American adolescents.The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.Prostasin: An Epithelial Sodium Channel Regulator.Host cell proteases: Critical determinants of coronavirus tropism and pathogenesisIbuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.Regulation of the epithelial Na+ channel by peptidases.Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itineraryProstasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.Membrane-anchored serine proteases in health and disease.Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy.Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development.Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation.Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells.Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells.Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin.Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.Recombinant hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2 cells, purification and crystallization.Hepatocyte growth factor activator inhibitor type 1 inhibits protease activity and proteolytic activation of human airway trypsin-like protease.
P2860
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P2860
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Identification of hepatocyte g ...... logical inhibitor of prostasin
@ast
Identification of hepatocyte g ...... logical inhibitor of prostasin
@en
Identification of hepatocyte g ...... logical inhibitor of prostasin
@nl
type
label
Identification of hepatocyte g ...... logical inhibitor of prostasin
@ast
Identification of hepatocyte g ...... logical inhibitor of prostasin
@en
Identification of hepatocyte g ...... logical inhibitor of prostasin
@nl
prefLabel
Identification of hepatocyte g ...... logical inhibitor of prostasin
@ast
Identification of hepatocyte g ...... logical inhibitor of prostasin
@en
Identification of hepatocyte g ...... logical inhibitor of prostasin
@nl
P2093
P2860
P356
P1476
Identification of hepatocyte g ...... logical inhibitor of prostasin
@en
P2093
Daniel Kirchhofer
Thomas D Wu
P2860
P304
P356
10.1074/JBC.M502119200
P407
P577
2005-10-14T00:00:00Z