Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors.
about
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effectsLesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNACrystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA.Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognitionStructure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNAAtomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylaseStructural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesInvestigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domainBiphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylaseSuppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) geneDependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairsThymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNARecent progress in the biology, chemistry and structural biology of DNA glycosylases.Base excision repair of tandem modifications in a methylated CpG dinucleotide.Human DNA mismatch repair in vitro operates independently of methylation status at CpG sitesE2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.Recent advances in the structural mechanisms of DNA glycosylasesInteraction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites.Substrate recognition by Escherichia coli MutY using substrate analogsStoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNAThe versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs.NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editingUncoupling of nucleotide flipping and DNA bending by the t4 pyrimidine dimer DNA glycosylase.Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1.Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases.Direct detection of chicken genomic DNA for gender determination by thymine-DNA glycosylase.Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts.A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.Kinetics of the action of thymine DNA glycosylase.Toxicity and repair of DNA adducts produced by the natural product yatakemycin.Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.
P2860
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P2860
Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Investigation of the mechanism ...... ase using designed inhibitors.
@ast
Investigation of the mechanism ...... ase using designed inhibitors.
@en
type
label
Investigation of the mechanism ...... ase using designed inhibitors.
@ast
Investigation of the mechanism ...... ase using designed inhibitors.
@en
prefLabel
Investigation of the mechanism ...... ase using designed inhibitors.
@ast
Investigation of the mechanism ...... ase using designed inhibitors.
@en
P2093
P2860
P356
P1476
Investigation of the mechanism ...... ase using designed inhibitors.
@en
P2093
G L Verdine
O D Schärer
P Gallinari
P2860
P304
P356
10.1073/PNAS.94.10.4878
P407
P577
1997-05-01T00:00:00Z