Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria
about
Improving enzymes for cancer gene therapy.Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cellsQuantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies.DNA polymerase active site is highly mutable: evolutionary consequences.Function-based isolation of novel enzymes from a large library.Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display.Engineering the elongation factor Tu for efficient selenoprotein synthesis.Discovery of superior enzymes by directed molecular evolution.A selection assay for haloalkane dehalogenase activity based on toxic substrates.Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity.Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression.Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipientsMultifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.DNA repair functions in heterologous cells.Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
P2860
Q30650758-9EA340C1-83FF-4BB7-8B86-D82116914B06Q30663736-C3C91A51-DFAE-430C-A562-582310315FBBQ30841593-FD082A3E-14B7-487D-B65B-BA460CF8AB40Q30869765-7463CE72-A10B-452B-8204-B60BC91B2EF6Q30936097-7909E529-82A3-4935-9B43-960761C86BC5Q33968014-30FC415A-9978-41C8-A011-FE13B43BA986Q34097187-A3D2E467-C1B3-4E59-B253-7F4FB49DDC87Q34115496-8448473D-0652-4FED-9795-7C9BBE890C1BQ34596533-C932BBF2-7CBC-4B04-84FD-85CD2FCF4F34Q35638773-D71DF223-94E3-4703-802C-957DF03B1634Q35862075-5B5589E2-EE7F-47CA-B8B0-E27933FD2FC3Q36401055-CC834CB8-6769-46A8-BDC3-47BC6C345DADQ37201951-415515EE-11C6-45BE-968F-DD09883D96CBQ37861732-73E2F11B-97E4-49DE-9892-7EB6B9785506Q41311787-03FC9C7A-9F4A-477C-BAE2-033B07A66F06Q53408388-016BFD9F-3940-4100-8517-F06FBFFD0399
P2860
Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@ast
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@en
type
label
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@ast
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@en
prefLabel
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@ast
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@en
P2860
P356
P1476
Novel human DNA alkyltransfera ...... genetic selection in bacteria
@en
P2093
F C Christians
P2860
P304
P356
10.1073/PNAS.93.12.6124
P407
P577
1996-06-01T00:00:00Z