Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization
about
Oxycodone combinations for pain relief.Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.Opioid-induced long-term potentiation in the spinal cord is a presynaptic event.Different effects of morphine and oxycodone in experimentally evoked hyperalgesia: a human translational study.How to design an opioid drug that causes reduced tolerance and dependence.The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neuronsActivation of µ-opioid receptors and block of Kir3 potassium channels and NMDA receptor conductance by L- and D-methadone in rat locus coeruleus.μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neuronsDifferential activation and trafficking of micro-opioid receptors in brain slices.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: modulation by kinases.Opioid receptor internalization contributes to dermorphin-mediated antinociceptionMechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Endomorphin-2: a biased agonist at the μ-opioid receptor.Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.A systematic review of combination step III opioid therapy in cancer pain: an EPCRC opioid guideline project.Evidence from basic research for opioid combinations.Opioid receptor targeting ligands for pain management: a review and update.Long-term efficacy, safety and tolerability of Remoxy for the management of chronic pain.Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons.Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.Desensitization and tolerance of mu opioid receptors on pontine Kolliker-Fuse neurons.Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model
P2860
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P2860
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Agonist-specific regulation of ...... recovery from desensitization
@ast
Agonist-specific regulation of ...... recovery from desensitization
@en
type
label
Agonist-specific regulation of ...... recovery from desensitization
@ast
Agonist-specific regulation of ...... recovery from desensitization
@en
prefLabel
Agonist-specific regulation of ...... recovery from desensitization
@ast
Agonist-specific regulation of ...... recovery from desensitization
@en
P2860
P356
P1476
Agonist-specific regulation of ...... recovery from desensitization
@en
P2093
John T Williams
Michael S Virk
P2860
P304
P356
10.1124/MOL.107.042952
P577
2008-01-15T00:00:00Z