Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. - Wikidata - wikimedia - TriplyDB

Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.

Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.

http://www.wikidata.org/entity/Q36835135

about

Platelet biogenesis and functions require correct protein O-glycosylation An important role of the SRC family kinase Lyn in stimulating platelet granule secretion Bernard-Soulier syndrome Proteolysis of platelet receptors in humans and other species.Stimulation of platelet apoptosis by peptidoglycan from Staphylococcus aureus 113.Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3.Role for ADAP in shear flow-induced platelet mechanotransduction.Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling.Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Distinct and overlapping functional roles of Src family kinases in mouse platelets.Signaling during platelet adhesion and activation Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis.The Y's that bind: negative regulators of Src family kinase activity in platelets.Platelet-neutrophil interactions under thromboinflammatory conditions Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.Multiple roles of Lyn kinase in myeloid cell signaling and function.Novel roles of cAMP/cGMP-dependent signaling in platelets.Src family kinases: at the forefront of platelet activation Of von Willebrand factor and platelets.New Concepts and Mechanisms of Platelet Activation Signaling.The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation.Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.Von Willebrand factor protects against acute CCl4-induced hepatotoxicity through phospho-p38 MAPK signaling pathway inhibition.Atractylodes lactone compounds inhibit platelet activation.ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury.Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading.Mechanism of anti-platelet activity of Oligoporus tephroleucus oligoporin A: involvement of extracellular signal-regulated kinase phosphorylation and cyclic nucleotide elevation.Drospirenone enhances GPIb-IX-V-mediated platelet activation.TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy.

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P2860

Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.

http://www.wikidata.org/entity/Q36835135

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Src family tyrosine kinase Lyn ...... ia the cGMP signaling pathway.

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type

label

Src family tyrosine kinase Lyn ...... ia the cGMP signaling pathway.

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prefLabel

Src family tyrosine kinase Lyn ...... ia the cGMP signaling pathway.

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BLOOD-2008-02-140970

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Src family tyrosine kinase Lyn ...... ia the cGMP signaling pathway.

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P2093

Clifford A Lowell

http://www.w3.org/2001/XMLSchema#string

Hong Yin

http://www.w3.org/2001/XMLSchema#string

Junling Liu

http://www.w3.org/2001/XMLSchema#string

Michael C Berndt

http://www.w3.org/2001/XMLSchema#string

Xiaoping Du

http://www.w3.org/2001/XMLSchema#string

Zhenyu Li

http://www.w3.org/2001/XMLSchema#string

P2860

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets

Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3

Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling

Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta

Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase.

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

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1139-1146

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10.1182/BLOOD-2008-02-140970

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4

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112

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2008-06-11T00:00:00Z

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5305879

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18550847

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2515128

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