Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology.
about
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's diseaseTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseEarly failure of the default-mode network and the pathogenesis of Alzheimer's diseaseGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseSleep, circadian rhythms, and the pathogenesis of Alzheimer diseaseInterictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathologyHippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planningOrexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer's disease-risk genesEvidence of association between sleep quality and APOE ε4 in healthy older adults: A pilot studyIncreased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriersSelf-reported sleep and β-amyloid deposition in community-dwelling older adults.Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's diseaseDiurnal oscillation of CSF Aβ and other AD biomarkers.Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life.Role of Sleep Disturbance in the Trajectory of Alzheimer's Disease.Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy.Neural Consequences of Chronic Short Sleep: Reversible or Lasting?Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesisRelationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila.Cognitive profiles in patients with multi-infarct dementia: an omani studySleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease.Sleep disorders, obesity, and aging: the role of orexinCircadian cycle-dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation.The sleep-wake cycle and Alzheimer's disease: what do we know?Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's diseaseDiurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.Circadian clock disruption in neurodegenerative diseases: cause and effect?Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's diseaseEffects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse modelSleep interacts with aβ to modulate intrinsic neuronal excitabilityA consensus in Korea regarding a protocol to reduce preanalytical sources of variability in the measurement of the cerebrospinal fluid biomarkers of Alzheimer's disease.Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivoAmyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer's Disease.Consequences of Circadian Disruption on Neurologic Health.Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology
P2860
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P2860
Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Disruption of the sleep-wake c ...... Alzheimer's disease pathology.
@en
type
label
Disruption of the sleep-wake c ...... Alzheimer's disease pathology.
@en
prefLabel
Disruption of the sleep-wake c ...... Alzheimer's disease pathology.
@en
P2093
P2860
P50
P1476
Disruption of the sleep-wake c ...... Alzheimer's disease pathology.
@en
P2093
Adam W Bero
Floy R Stewart
Tom Kasten
Yafei Huang
P2860
P304
P356
10.1126/SCITRANSLMED.3004291
P407
P577
2012-09-01T00:00:00Z