A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
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The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding modeDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionStructure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitorsThe indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships.Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).Topoisomerase inhibitors as anticancer agents: a patent update.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.C4-substituted isoquinolines: synthesis and cytotoxic action.DNA cleavage assay for the identification of topoisomerase I inhibitors.
P2860
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P2860
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
@zh-cn
name
A systematic study of nitrated ...... ent topoisomerase I inhibitor.
@en
type
label
A systematic study of nitrated ...... ent topoisomerase I inhibitor.
@en
prefLabel
A systematic study of nitrated ...... ent topoisomerase I inhibitor.
@en
P2093
P2860
P356
P1476
A systematic study of nitrated ...... ent topoisomerase I inhibitor.
@en
P2093
Andrew Morrell
Glenda Kohlhagen
Mark Cushman
Smitha Antony
P2860
P304
P356
10.1021/JM060974N
P407
P50
P577
2006-12-01T00:00:00Z