Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.
about
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P538-Oxoguanine rearranges the active site of human topoisomerase IStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesTDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoRad50 is dispensable for the maintenance and viability of postmitotic tissuesThe structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding modeSynthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationshipsSynthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen HeterocyclesDesign, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer AgentsSingle-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.The p14ARF alternate reading frame protein enhances DNA binding of topoisomerase I by interacting with the serine 506-phosphorylated core domain.Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal siteMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsDesign, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationA human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro.Human mitochondrial topoisomerase IConversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.Poisoning of mitochondrial topoisomerase I by lamellarin DAnalysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complexMutagenic processing of ribonucleotides in DNA by yeast topoisomerase IPoly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.Neurological disorders associated with DNA strand-break processing enzymes.Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae.Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.Recognition and repair of chemically heterogeneous structures at DNA endsBenzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair.Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships.Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
P2860
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P2860
Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Induction of reversible comple ...... guanine and 5-hydroxycytosine.
@en
type
label
Induction of reversible comple ...... guanine and 5-hydroxycytosine.
@en
prefLabel
Induction of reversible comple ...... guanine and 5-hydroxycytosine.
@en
P2093
P2860
P356
P1476
Induction of reversible comple ...... guanine and 5-hydroxycytosine.
@en
P2093
Bjornsti MA
Essigmann JM
Pourquier P
P2860
P304
P356
10.1074/JBC.274.13.8516
P407
P577
1999-03-01T00:00:00Z