Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites
about
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityGadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatinDiarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitorsDOSY NMR and MALDI-TOF evidence of covalent binding the DNA duplex by trimethylammonium salts of topotecan upon near UV irradiation.A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA.Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622.Towards Antitumor Active trans-Platinum Compounds.Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents.Natural triterpenoid avicins selectively induce tumor cell deathBenzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbationPoisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.Structural studies of type I topoisomerases.Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenineWide-spectrum characterization of trabectedin: biology, clinical activity and future perspectives.Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site.Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine.Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site. Implications for the role of lysine 136 in DNA binding.Cellular resistance to camptothecins.Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.Telomeric DNA damage by topoisomerase I. A possible mechanism for cell killing by camptothecin.DNA cleavage assay for the identification of topoisomerase I inhibitors.Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
P2860
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P2860
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@ast
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@en
type
label
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@ast
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@en
prefLabel
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@ast
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@en
P2093
P2860
P356
P1476
Interaction of an alkylating c ...... isomerase I-DNA cleavage sites
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.19.8861
P407
P577
1995-09-01T00:00:00Z