Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
about
Molecular mechanisms and regulation of urinary acidificationThe Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrheaNHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.Luminal Na(+)/H (+) exchange in the proximal tubuleContribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.Occludin S408 phosphorylation regulates tight junction protein interactions and barrier functionCyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation siteChloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activityRegulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.Applications of proteomics in the study of inflammatory bowel diseases: Current status and future directions with available technologies.Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3NHE3 regulatory complexesAKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.The serine 814 of TRPC6 is phosphorylated under unstimulated conditions.Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca(2+), cGMP and lysophosphatidic acid.D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent processTrafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells.The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans.
P2860
Q26823086-1D7C7F4E-4840-4C53-A658-3657F715FF69Q28385670-8715EE2E-7381-454E-BCEE-BCB69CE45E21Q33727744-C7E776B6-43CF-44F4-8EA6-7089F223F5C8Q33884278-E6C38661-281F-4F8A-9717-7895989BD871Q34022687-42C18848-586D-4F10-8821-1AFD79E429D4Q34043225-290F5CCB-4306-4827-B50B-FDBB89057FB3Q34251172-EFB2F493-66F7-47BC-98E1-C3AB4581FDF0Q34782190-4E40CA28-85AA-402E-A55D-8F8F67EE24C7Q34918139-8087677E-DA16-4016-A81C-627124EF190BQ35002780-B242D92B-883D-4B6C-9E49-DC4A39090723Q35067687-40060F77-F4F1-4B1B-B26E-07995384D551Q35266484-87F8C781-C46F-49EE-8AA6-2E637F9E76BCQ35572593-26B99467-09FA-40BE-BB4A-AFBCF043F752Q35813335-84EF8A0C-48A5-4C7A-B012-F471140427CCQ35921733-66B790C6-5BE9-406D-B346-3A0D7C9B1EFBQ37155926-842FD388-1908-40D5-B6C8-11B7047C0975Q37339302-D2DC9153-BFEB-4B0D-BCAF-F73E9A43798CQ37462304-AFDD6C63-DED0-40FD-9604-6969E3E522F6Q37485479-3BB62253-516B-4FC9-B87C-082E4735ED1BQ37608417-F846027D-FD5C-4CA6-AD31-2F09E2296459Q38712681-5998FE2D-9FEB-4F76-9D8B-5A257722E619Q39597237-81C78ABB-B45D-4E14-B240-8137C14E0DBEQ41001492-A4F1B393-4D63-4871-A77E-75960654132CQ42486012-95DB9679-19AF-4444-BD97-3B2AED083D5DQ42514629-FEE7A51D-6464-41C5-AB84-B72411FBD076Q42586814-8A6AEC35-7DC8-41F1-AA91-E822D32DE430Q47144215-4BE47B7F-6DFD-4572-BC49-54BE42300B5BQ51763381-6ED91D0E-D437-44B6-A8E8-59A8E8B4F7EEQ52774162-414C64C1-639B-4E02-94DE-01C244EB14AE
P2860
Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Casein kinase 2 binds to the C ...... lating a separate site in NHE3
@en
type
label
Casein kinase 2 binds to the C ...... lating a separate site in NHE3
@en
prefLabel
Casein kinase 2 binds to the C ...... lating a separate site in NHE3
@en
P2093
P2860
P356
P1476
Casein kinase 2 binds to the C ...... lating a separate site in NHE3
@en
P2093
Akhilesh Pandey
Boyoung Cha
David Litchfield
Mads Grønborg
Mark Donowitz
Rafiquel Sarker
Sachin Mohan
Yueping Chen
P2860
P304
P356
10.1091/MBC.E08-01-0019
P577
2008-07-09T00:00:00Z